Berkeley Madonna is a mathematical modelling software package, developed at the University of California at Berkeley by Robert Macey and George Oster.
[1] [2] Its strength lies in a relatively simple syntax to define differential equations coupled with a simple yet powerful user interface.
In particular, Berkeley Madonna provides the facility of putting parameters onto a slider that can in turn be moved by a user to change the value.
It has become a standard in the development and communication of pharmacometric models describing drug concentration and its effects in drug development [3] [4] as well as modeling of physiological processes.
The use of system dynamics modeling has expanded into other areas such as system physics, epidemiology,[7] environmental health,[8] and population ecology.