Near the current Berlin Ringbahn and the Prussian Northern Railway, the line formerly had a separate alignment, but this was abandoned in 1897.

Before reaching the Berlin city limits north of Buch, the line has no significant curves.

It was hoped that 39,000 people and 20,000 tons of freight would be transported annually and that with an estimated construction cost of 2.5 million thalers this would provide a return of just over five percent.

The increase was largely due to upgraded standards, such as the use of better structures and the placement of the Stettin station next to the Oder in the middle of the business district.

The second track from Berlin to Angermünde was put into operation on 22 December 1863 and on 1 August 1873 the work which had begun in 1872 on doubling the Angermünde–Stettin–Stargard line was completed.

On 12 December 1897 the line along Grüntaler Straße in the Berlin district of Wedding, which had several level crossings, was moved on to the route of the Ringbahn to connect with the new transfer station of Gesundbrunnen.

The rapid growth of road transport at the beginning of the twentieth century led to chaotic conditions at level crossings, requiring the separation of the modes.

This was carried out in several stages between 1912 and 1916 by creating embankments from Berlin to Bernau and separating long-distance and suburban tracks.

Originally it had been planned to use the usual German AC system of overhead electrification with 16.7 kilovolts and 15 hertz.

However, while construction work was in full swing – in Pankow the first electric pylons had already been erected –German Railways decided in favour of a DC system with side-contact conductor rail at 750 volts.

On 8 August 1924, the first electric commuter train line was opened between the Stettiner suburban station and Bernau.

As a result of the boundary change after the Second World War, the city of Stettin became part of Poland in 1945 and was renamed Szczecin.

The cross-border traffic between Angermünde and Szczecin declined significantly after the war, as Stettin's German-speaking population had been expelled in totality.

The closure of the station on 18 May 1952 meant the temporary end of rail operations on the Szczecin Railway in West Berlin.