It is situated in the Gesundbrunnen district, part of the central Mitte borough, as an interconnection point between the northern Ringbahn and Nord-Süd Tunnel lines of the Berlin S-Bahn, as well as a regional and long distance station of the Deutsche Bahn network.

On 8 August 1924 Gesundbrunnen was one of the first stations to become part of the Berlin S-Bahn system when third rail trains ran from Stettiner Bahnhof to Bernau.

Plans for an access of Gesundbrunnen station to the Berlin U-Bahn network were already developed by the AEG electric company prior to World War I.

Designed in a New Objectivity style according to plans by Alfred Grenander with a separate reception building, the U-Bahn platform crossed deep beneath the railway tracks and served as an air-raid shelter during the bombing of Berlin in World War II.

The planning resumed during 2010 and construction work on a new entrance building began by the end of 2011, with the 3300 square meters projected to cost a total of 7.4 million euros.