The U-Bahn station opened in 1910 with the original name Hauptstraße, named after the section of the Reichsstraße 1 running through the districts of Schöneberg and Friedenau.

After the underground station had been badly damaged in World War II, it was put back into operation on 16 December 1945.

The access on the central island on Innsbrucker Platz was closed, instead, a new entrance was created north of the square, on Innsbrucker Straße, in a glazed pavilion typical to the style of the 1950s, which led directly to the platform via a staircase.

Between 1971 and 1979, the construction of the Stadtautobahn 100, built through a tunnel under the Innsbrucker Platz, made a further conversion to the U-Bahn station necessary.

Between the road surface and the motorway tunnel, a large distribution floor was created, and the southern tunnel of the existing subway was separated.