In 1999, she resigned from the Union for French Democracy to challenge Anne-Marie Comparini as President of the Regional council of Rhône-Alpes in place of Charles Millon.
[citation needed] Isaac-Sibille was elected to the National Assembly in 1988 to represent Rhône's 1st constituency, defeating the Socialist Party's Gérard Collomb.
She also served as president of the association for the Médaille de la Famille française.
[citation needed] Born Bernadette Sibille, she married Alain Isaac on 14 January 1957, and they remained together until his death in April 2017.
[8] They had four children, including Democratic Movement politician Cyrille Isaac-Sibille.