On 24 September 1951, he became a deputy secretary in the civil service of French Equatorial Africa.

Ayandho worked in the payment service in Bangui from 1951 to 1954, at which time he became secretary to Fort Crampel.

He received further education at the Ecole national de la France d'outre-mer, and after graduation returned to the Central African Republic.

Ayandho became deputy minister of economic planning and technical assistance on 28 February 1969, then head of the ministry on 17 September.

He became regional representative for Air Afrique in Gabon on 31 December, and was appointed economic counselor at the Central African Republic embassy in Libreville on 27 September 1975.