Moret was born in 1953 in Vevey Switzerland, and did his undergraduate studies at the École Polytechnique Fédérale de Lausanne (EPFL), graduating in 1975.
He then joined the faculty of the University of New Mexico, where he remained until 2006, when he moved to EPFL.
[3] In 2001, Moret founded the Workshop in Algorithms for Bioinformatics (WABI) and remains on the Steering Committee for the conference.
With H. D. Shapiro, he is the co-author of Algorithms from P to NP, Volume I: Design and Efficiency (Benjamin Cummings, 1991).
He has also written many highly cited research papers in bioinformatics, including papers on calculating the minimum genetic rearrangement distance between a pair of related genomes[5] and on evolutionary tree reconstruction.