[4] Bernardino de Leis was ordained a priest in the Canons Regular of the Lateran.
[5][6] On 27 October 1501, he was appointed during the papacy of Pope Alexander VI as Bishop of Ischia.
[4]{[5][6] On 8 January 1504, he was appointed during the papacy of Pope Julius II as Bishop of Castro di Puglia.
[3][5][6] On 19 January 1504, he was appointed during the papacy of Pope Julius II as Bishop of Lavello.
[2][5][6] On 23 February 1504, he was appointed during the papacy of Pope Julius II as Bishop of Cagli.