Oligarch, banker, ambassador and man of letters, he is today remembered principally for the meetings of the members of the Accademia Platonica in the Orti Oricellari, the gardens of his house in Florence, the Palazzo Rucellai, where Niccolò Machiavelli gave readings of his Discorsi.

[2]: 29  Giovanni Rucellai remained loyal to Strozzi after the banishment of the latter to Padova by Cosimo de' Medici in November 1434, and for about 27 years he took no part in public life.

[4]: 103 The couple had five children: Cosimo, Palla, Piero, Giovanni and Lucrezia; it is likely that Tommaso Masini da Peretola was an illegitimate son of Rucellai.

[2]: 29  Sixtus gave Lorenzo two marble heads, of Augustus and of Agrippa, allowed him to buy precious items belonging to his predecessor, Paul II, and confirmed that the Medici would continue as papal bankers and as agents for the alum mines at Tolfa.

[4]: 101 After the death of Lorenzo de' Medici, he opened his gardens, the Orti Oricellari, to the Accademia Platonica in order that they might continue their discussions about literature, classical heritage, rhetoric and Latin grammar.

In 1474, after Niccolò Vitelli was besieged by papal forces under Giuliano della Rovere (later pope Julius II) in Città di Castello, Rucellai wrote an Oratio de auxilio Tifernatibus adferendo.