She sang with the Metropolitan Opera from 1908 to 1917, and was the first American woman elected to membership in the Accademia Filarmonica Romana.

Her uncle was Joshua James, a noted sea captain and commander of civilian life-saving crews.

[7][8] She sang in London in 1905,[9] Italy in 1906 and 1907, in Mexico City in 1908, in Havana in 1915, and at the Pan-American Exposition in San Diego in 1916.

"[13] In 1924, De Pasquali became the first American woman elected to membership in the Accademia Filarmonica Romana.

She was widowed in 1923, and she died in Omaha, Nebraska in 1925, aged 51 years, after weeks of pneumonia while touring on the vaudeville circuit.