Before European settlers arrived in the Tulpehocken Creek valley, the area was inhabited by the Lenape people.

[4] In 1723, thirty-three Palatine families from Schoharie, New York, moved to the confluences of the Tulpehocken and Northkill Creeks.

[5][6][7] By 1735, a saw and grist mill was located three and a half miles up the Tulpehocken river from Bernville.

[8] In 1737, Stephanus Umbenhauer immigrated from Bern, Switzerland, and purchased 220 acres (0.89 km2) from Thomas Penn.

In 1819, Stephanus' grandson, Johann Thomas Umbenhauer, set aside 46 acres (190,000 m2) to be divided into 62 lots.

An historic marker on Route 183 states: "The canal, at this point, followed the north bank of the Tulpehocken.

A dam, two locks, and a mule bridge made it possible for boats to cross Northkill Creek.

[12][13] In 1851, the village of Bernville, discontented with Penn Township's road maintenance and community services, incorporated as a borough.

In 1950, Bernville Borough annexed property from Penn Township at both ends of Main Street.

Stanton Clay Park, on the corner of Third Street and Penn Valley Road, is home to a gazebo and a small field.

Blue Marsh Lake is a popular recreation site, offering hiking, boating, and fishing.

A levee along Northkill Creek protects Bernville from Blue Marsh flooding above 300 feet (91 m) elevation.

Two covered bridges, which no longer exist, crossed Northkill Creek, connecting Bernville with Jefferson Township.