The Berwick area was granted to several New England Planter families in 1760 but the community was not settled until 1810 when Benjamin Congdon built on the townsite.

Berwick had rail service until the Dominion Atlantic Railway abandoned the former W&AR main line through town in March 1990.

Following the collapse of the traditional European market for apples during and after World War II, area farmers began diversifying their operations throughout the 1950s and 1960s.

Until recently a number of regionally successful small manufacturers related to agriculture prospered in Berwick, including the M.W.

[9] Other employers include the Easson's trucking firm, the Michelin tire plant in nearby Waterville and the military base at CFB Greenwood.

The town functions as a service centre for adjacent areas of Kings County with a number of small retailers.

[10] Berwick's late 19th and early 20th century prosperity driven by the apple industry left the town with many fine homes and classic wooden Victorian storefronts.

The Bethune House, an Arts and Crafts style home of a noted early 20th century regional photographer was demolished in 2008 to create a parking lot.

The arena includes a 200-metre running track, the Berwick Fitness Centre, and an ice rink that are partially lit with natural light.

Margaret Marshall Saunders, author of the 1894 children's book, Beautiful Joe spent most of her childhood in Berwick where her father served as Baptist minister.

A homeless man named Harley Lawrence was found dead in a burned-out bus shelter in Berwick in October 2013.