De la Cruz won the Most Valuable Player award when she helped her Dominican professional club Mirador to win the Championship.

[3] She became the MVP of the 2006 TV Azteca's Women Stars Volleyball Cup, played in Monterrey, Mexico won by the team with a perfect record in 5 matches.

[17] In June 2009, at the 2010 World Championship NORCECA Qualification Pool H, at Santiago de los Caballeros, Dominican Republic, she won the Best Spiker award.

[22] Returning from the sabbatical year, De La Cruz joined her National Senior Team winning the 2010 Final Four Cup gold medal.

[24] During the final series, Bethania left the team to participate with Mirador at the World Club Championship,[25] taking the fourth place.

[29] De la Cruz set a new record in serving,[30] with 57 aces, topped the scorers with 392 points[31] and won the Most valuable player award.

[34] Bethania crowned the season winning the Puerto Rico League Championship, sweeping the final series against the Mets de Guaynabo.

[39] As the key player for her team, she was four times the Top Scorer by day and had three of the five best performances during the competition, including 42 points Vs. Germany on November 12.

[42] De la Cruz joined the Turkish club Eczacıbaşı VitrA[43] and help them win the 2014–15 CEV Champions League by defeating 3-0 to the Italian Yamamay Busto Arsizio.

[57] she was awarded jointly with Brayelin Martinez 2019 Vollyeball Athlete of the Year by the Dominican Republic Guild of Sport Writers.