She won the Silver Medal with the National Junior Team at 2002 NORCECA Youth Girls' Volleyball Championship and was selected tournament "Best Setter".

[2] Same year she participated at the 2002 World Championships with the National Senior Team at the age of 15,[3] making her the youngest player at the competition.

[5] In beach volleyball she won the bronze medal at the 2006 National Championship, playing with Bethania de la Cruz.

During the Holy Week Sport Festival held in Hato Mayor, Echenique played Beach Volleyball (three) with Bethania Almanzar and Dahiana Burgos, winning the silver medal of the event.

[7][8] Karla played for Gigantes de Carolina for the Puerto Rican LVSF in the 2010 season,[9][10] being awarded by Statistics as "Best Setter",[11] and was also selected to the All-Star game.