Betsy L. Humphreys (born April 26, 1947) is an American medical librarian and health informatician known for leading the cross-institutional efforts to establish biomedical terminology standards such as SNOMED CT and the Unified Medical Language System.

[3] Betsy Humphreys was born in Lowell, Massachusetts, the middle child of three.

[3][5] Throughout her time at NLM, Humphreys worked to automate library processes and was instrumental in launching DOCLINE.

[6][7] From 2005 to June 30, 2017, Humphreys served as deputy director of the National Library of Medicine's.

[7] Additionally, from 2015 to 2016, she served as the acting director, becoming the first woman and the first librarian to direct the National Library of Medicine.