The second season also contained cameo appearances by Victoria Beckham, Bow Wow, Naomi Campbell, Kenneth Cole, Nina García, Larry King, Roberta Myers, Omarion, Gene Simmons, Christian Siriano, Vera Wang, Betty White and Joe Zee, all appearing as themselves.

Notes: Walt Disney Studios Home Entertainment release of Ugly Betty Season Second, subtitled "Brighter, Bolder, Bettyer", would be September 9, 2008 in the United States and Canada.

Channel 4 was originally scheduled to take a three-week break at Christmas and resume episodes in January; this hadn't happened.

Channel 4 decided to wait until September after Big Brother 2008 had finished airing, as the episodes took up approximately 100 minutes of airtime on a Friday night, which filled Betty's slot.

Prior to Big Brother, March–May was filled with the whole first season of Dirty Sexy Money, which occupied Betty's slot whenever it was not on, and moved accordingly.

Betty made its return to Channel 4 on Friday 5 September 2008 between the two season finale episodes of Big Brother.