Betty R. De Boef (born February 19, 1951) is an American politician in the state of Iowa.

She was a member of the Oskaloosa Christian Women's Club and the Mahaska County Republican Central Committee.

She married her husband, Harold De Boef, on February 20, 1971, and the couple have two sons and two daughters.

[1] De Boef was first elected to the Iowa House of Representatives for the 96th district in 2001, a position that she held until 2003.

De Boef was re-elected in 2006 with 5,819 votes (54%), defeating Democratic opponent Christopher Hontross.