Greene was born in Seattle on 24 June 1920, and started taking flying lessons in 1936.
[1][2] She studied at the University of Washington and served in the Women Airforce Service Pilots in World War II.
[3] Greene was a devout Presbyterian, and helped found Mission Aviation Fellowship.
[4] She made its first flight in 1946 when she transported two missionaries of Wycliffe Bible Translators in a Waco UPF-7 biplane to a remote jungle location in Mexico.
[4][8] She was inducted into the Women in Aviation International Pioneer Hall of Fame in 2017.