Directed by Alex Zamm, and starring George Lopez, Odette Annable and Zachary Gordon, the film focuses on Papi and Chloe, now married with five puppies.

The film was released by Walt Disney Studios Home Entertainment on February 1, 2011, in a two-disc Blu-ray and DVD combo pack.

[4] Two years after the events of the first film, newly married couple Papi (George Lopez) and Chloe (Odette Yustman)[5] are trying to keep up with their five puppies Papi Jr, Lala, Rosa, Ali and Pep (voiced by Zachary Gordon, Madison Pettis, Chantilly Spalan, Delaney Jones and Emily Osment) running around the house, creating problem after problem.

Aunt Viv (Susan Blakely), Chloe's owner, is in the rain forest for the next 6 months with her niece, Rachel (Erin Cahill) searching for plants for medical research.

Sam takes Chloe, Papi and the puppies back home to meet his parents, Mr. and Mrs. Cortez (Castulo Guerra and Lupe Ontiveros).

Later, Papi initially wins the dog show, but is later disqualified due to lack of breed papers (Pedigree [Purebred indication]), losing to an arrogant and vain French poodle named Appoline (Bridgit Mendler).

[8] The video begins with Mendler traveling in an old red and white kombi, leaving Beverly Hills and going to Baja California, Mexico.