According to architectural editor Dreck Spurlock Wilson, she was "believed to have been the first African-American female licensed as an architect in the United States.

[8] A 1945 newspaper report about the Metropolitan Life Insurance Company's development project at Stuyvesant Town led Greene to move to New York City.

She submitted her application to help design it, in spite of the developer's racially segregated housing plans; and much to her surprise, she was hired.

Though she remained in Rosefield's employ until 1955, Greene worked with Edward Durell Stone on at least two projects in the early 1950s.

In 1951, she was involved with the project to build the theater at the University of Arkansas and in 1952, she helped plan the Arts Complex at Sarah Lawrence College.