Her research in yeast has advanced the molecular understanding of the cell biology underlying human cancer, cardiovascular disease, lysosomal-storage disorders and infections.

[2] On May 16, 2014, Wendland was selected to be interim dean of the Krieger School of Arts and Sciences after then-dean Katherine Newman announced she was accepting another position at the University of Massachusetts Amherst.

[10] As dean, Wendland raised $747 million for the Krieger School of Arts and Sciences and helped establish the SNF Agora Institute, which seeks to strengthen global democracy.

[11] Wendland also focused on personalizing the undergraduate student experience with the introduction of active learning techniques, small seminar courses, and additional research opportunities.

Wendland has been credited with increasing the diversity of faculty and creating a more inclusive climate in the Krieger School of Arts and Sciences.