Directed by Bob Persichetti and Justin K. Thompson from a screenplay written by Phil Lord and Christopher Miller alongside David Callaham, the film stars Shameik Moore as the voice of Miles, alongside Jason Schwartzman and Karan Soni.

Early work coincided with Across the Spider-Verse's production before that film was prioritized first and the script and animation of Beyond were subsequently changed significantly.

Additionally, Jharrel Jerome is set to reprise his voice role as the Earth-42 version of Miles G. Morales / Prowler from the cliffhanger ending of the preceding film, Spider-Man: Across the Spider-Verse (2023).

[5] By November 2018, ahead of the release of Spider-Man: Into the Spider-Verse (2018) the next month, Sony Pictures Animation had begun development on a sequel to the film.

[16] The following month, Sony removed Beyond the Spider-Verse from its release schedule due to the 2023 SAG-AFTRA strike, which prevented the voice cast from recording dialogue.

[17] After the strike ended in November, voice recording for Beyond the Spider-Verse was set to resume imminently, although, it was unclear if the film would still be released in 2024.

[19] Lord reiterated this the next month when he said it would further emotionally explore Miles and the character's relationships with his parents, Gwen Stacy / Spider-Woman, and Peter B. Parker.

[23][24] After Sony Pictures CEO Tony Vinciquerra said in May 2024 that the studio was exploring different opportunities to make their films less expensive and more efficient by primarily using artificial intelligence (AI), which was a central issue in the 2023 Hollywood labor disputes,[25] Miller responded to concerns regarding the use of AI in Beyond the Spider-Verse, stating that generative artificial intelligence would not be used in the film.

Some machine learning technology, which is distinct from generative AI as it is based on work already done on the project, had been used by Sony Pictures Imageworks to assist animators during the production of the franchise's preceding films.

He admitted that they felt pressured in making the film as the trilogy's conclusion because they had set a high bar for themselves, explaining that they sought to avoid repeating the "mistakes" of the third installments in other franchises, such as The Godfather Part III (1990).

[5] In January 2024, Jake Johnson expressed interest in reprising his role as Peter B. Parker from the prior films and had pitched ideas for the character's return to Lord.

[35][36] Netflix signed for exclusive "pay 1 window" streaming rights, which is typically an 18-month window and included the sequels to Spider-Man: Into the Spider-Verse; this deal built on an existing output deal that Netflix had signed with Sony Pictures Animation in 2014.