Through a series of adventures he eventually gains the love of his big brother George, (Jonathan Lipnicki), acceptance by the extended Little family, and even the grudging tolerance of the family cat Snowbell (voiced by Nathan Lane), who is a member of an alley cat Mafia-like gang that wants to eliminate Stuart.

Fox) and his brother George (Jonathan Lipnicki) are attending school together, but his mother (Geena Davis) doesn't seem to think Stuart is capable of taking care of himself.

Stuart signs up to be a lake-scout in an attempt to prove to his mother (voiced by Geena Davis) that he doesn't need to be watched over all the time.

Soon, Stuart meets a new friend: a skunk named Reeko (voiced by Wayne Brady) whom he quickly befriends.

It was reported by the Tracking Board and Zimbio that a new Stuart Little film was in development by Sony Pictures Animation and Red Wagon Productions with Douglas Wick and Lucy Fisher returning as the producers.

On October 3, 2023, it was announced an animated series reboot of Stuart Little is currently in the works at Sony Pictures Television Kids.

[4] An animated series taking place between the events of the second and third films premiered on HBO Family on March 1, 2003.