He was elected in a by-election to the Andhra Pradesh Legislative Assembly in 1992[1] after the sudden death of his brother, Bhuma Sekhar Reddy, an MLA from Allagadda constituency in Kurnool district.

In 1996, Reddy was the Telugu Desam Party candidate against Prime Minister P. V. Narasimha Rao in the Nandyal Lok Sabha constituency election.

As the family had been involved in local politics, Bali Reddy wanted to send his son away for his education.

Nagi Reddy completed his intermediate studies in Velankanni at a private school affiliated with the Central Board of Secondary Education.

He married Shobha Nagi Reddy, daughter of former Andhra Pradesh minister S. V. Subbareddy, who also became a renowned politician.

[4] Nagi Reddy began his political career in 1984, when he was elected president of the Rudravaram Cooperative Society.

[5] The result inspired Nagi Reddy to rebuild his political strategy and improve his relationship with the party core.

[8] Nagi Reddy and his daughter, Bhuma Akhila Priya (the Allagadda MLA) returned to the TDP in 2016.