Bhupinder Singh was born in Amritsar, Punjab to Natha Singhji, a musician and his introducer to music.

[2] Singh started his career as a casual artist for All India Radio under the direction of Satish Bhatia.

He was given the opportunity to sing the song Hoke Majboor Mujhe Usne Bulaya Hoga alongside Mohammed Rafi, Talat Mahmood and Manna Dey in Chetan Anand's Haqeeqat.

His famous songs include "Dil Dhoondta hai", "Do diwane shahar mein", "Naam gum jayega", "Karoge yaad to", "Thodi si Zameen Thoda Aasman", "Meethe bol bole", "Kabhi kisi ko mukammal", "Kisi nazar ko tera intezaar aaj bhi", and "Ek akela is Shehar Mein".

He sang the song Duniya Chute Yaar Na Toote picturized on Rajesh Khanna.