As of April 2016,[update] she is signed to WWE, where she performs on the SmackDown brand under the ring name Bianca Belair.

Blair attended Austin-East Magnet High School in Knoxville, Tennessee, where she succeeded in many sports such as track.

Blair was forced to abandon her CrossFit career due to intercostal chondritis, also known as shifting rib syndrome, which she attributed to overtraining.

[9][11][12] Blair entered her information into the WWE prospects database shortly after the premature end of her CrossFit career "more on a whim than with an actual plan", according to Hurd.

[18] In January 2018, Belair began an undefeated streak by defeating various competitors[19][20] including Lacey Evans,[21] Candice LeRae,[22] Dakota Kai[23] and Deonna Purrazzo.

[25] On January 26, 2019, at TakeOver: Phoenix, Belair unsuccessfully challenged Shayna Baszler for the NXT Women's Championship after interference from Jessamyn Duke and Marina Shafir, ending her undefeated streak at 367 days.

[26] At TakeOver: New York, Belair failed to win the title as she was submitted by Baszler in a fatal four-way match also involving Kairi Sane and Io Shirai.

[44] At the first night of WrestleMania, Belair defeated Banks in the main event to win the SmackDown Women's Championship, marking her first title in her career.

"[53] At Extreme Rules, Belair defeated Lynch by disqualification due to interference by a returning Sasha Banks, thus not earning the title.

[55] At Crown Jewel, Belair failed to regain the title in a triple threat match against Lynch and Banks.

[57] At Survivor Series, Belair made history by becoming the first person to overcome a four-on-one handicap to win the event's traditional five-on-five elimination match.

[62] Belair retained her title against WWE official Sonya Deville on the April 25 episode of Raw, despite interference from Carmella and Queen Zelina.

[63] Belair then retained the title against Asuka and Lynch in a triple threat match at Hell in a Cell,[64] and against Carmella at Money in the Bank.

[68] On the August 8 episode of Raw, they challenged Belair, Alexa Bliss, and Asuka to a six-woman tag team match at Clash at the Castle, which they accepted.

[74] Three weeks later at Survivor Series: WarGames, Belair, Asuka, Bliss, Lynch, and Mia Yim defeated Damage CTRL (Bayley, Kai, Sky), Nikki Cross, and Rhea Ripley in a WarGames match after Lynch pinned Kai.

[83] At SummerSlam, Belair regained the title by defeating Asuka and Charlotte Flair in a triple threat match to win her second WWE Women's Championship.

[84] After a two-month hiatus, Belair challenged Sky for the title at Crown Jewel[85] but was unsuccessful due to interference by a returning Kairi Sane.

[90] In May 2024 at Backlash France, Belair and Cargill defeated Damage CTRL's The Kabuki Warriors (Asuka and Sane) to win the WWE Women's Tag Team Championship.

[92] Belair then participated in the 2024 Queen of the Ring tournament, defeating Candice LeRae in the first round,[93] and Tiffany Stratton in the quarterfinals.

[95] At King and Queen of the Ring, Belair and Cargill defended their titles against Candice LeRae and Indi Hartwell.

[111] Belair is the cover star for the WWE 2K24 Deluxe Edition alongside Demi Bennett, who wrestles as Rhea Ripley.

[12] Her grandfather Edward G. High was a professor and chairman of biochemistry at Meharry Medical College, her great-grandfather Edward N. Toole was the first licensed African American electrician in Durham, North Carolina, and her aunt Miranda Hunt was one of the first African Americans to integrate St. Cecilia High School in Nashville, Tennessee.

[13] On June 9, 2017, Blair announced that she was engaged to fellow professional wrestler Kenneth Crawford, better known as Montez Ford.