Biblis lies directly north of the lower reaches of the Weschnitz, which empties into the Rhine only a few kilometres northwest of the municipality.

In 836, Biblis had its first documentary mention in the Lorsch Abbey’s Codex Laureshamensis under the name Bibifloz (“settlement at the water”) when King Louis the German donated his holdings in Biblis, Wattenheim and Zullestein to his faithful vassal Wernher, who in turn bequeathed them to the Lorsch Abbey in 846.

During the Thirty Years' War, the municipality was laid waste several times, and the populace was decimated by the Plague.

The airfield was used during World War II to intercept allied bombers and is an equestrian centre and restaurant today.

The plans for the current church were drawn up by the then Grand Duchy of Hesse district building master Christian Horst.

Under Rabbi Salomon Bodenheimer (1813–1886), a Talmud-Torah school and other institutions were founded, which were of great importance to Jews far beyond as well as in Biblis.

Near Nordheim, three parallel high-voltage network overhead transmission lines cross the Rhine on pylons up to 103 m tall.