The route runs through the western part of the state, passing through the Pittsburgh area.

The route runs through the central mountains of the state, passing through numerous stream valleys.

The route utilizes the York County Heritage Rail Trail between York and the Maryland border, where it connects to the Torrey C. Brown Rail Trail, which heads south towards the Baltimore, Maryland area.

It runs through Gettysburg National Military Park and continues until the Maryland border just south of Fairplay.

The route runs through the eastern part of the state, passing through the Lehigh Valley and the Scranton/Wilkes-Barre area.

[7] BicyclePA Route S runs from the West Virginia border in West Alexander, Washington County east to the New Jersey border at the Delaware River in Washington Crossing, Bucks County.

It utilizes the Youghiogheny River Trail in western Pennsylvania, which is part of the Great Allegheny Passage.

[11] BicyclePA Route Z, which is entirely located in Erie County, runs from the Ohio border west of West Springfield to the New York border east of North East, where it connects to the Seaway Trail.