As of August 2021[update], it consists of three segments, running though North Dakota, Wisconsin, Ohio, and Pennsylvania in the United States.

The middle segment runs across Wisconsin for 269 miles (433 km) from the Mississippi River near Winona, Minnesota, to the Lake Express ferry terminal in Milwaukee, where it will eventually cross Lake Michigan to Muskegon, Michigan.

[2] When fully complete, USBR 30 is expected to run across much of the country running from New Hampshire's Seacoast at USBR 1, incorporating a ferry crossing across Lake Michigan to a future junction with USBR 76 near West Yellowstone, Montana, running through New Hampshire, Vermont, New York, Pennsylvania, Ohio, Michigan, Wisconsin, Minnesota, South Dakota, North Dakota, and Montana along the way.

USBR 30 was first designated by the American Association of State Highway and Transportation Officials (AASHTO) in September 2018 along BikePA Route Z in Pennsylvania.

[4] In the fall of 2020, AASHTO designated the segment in Wisconsin, which runs from the Mississippi River at the Minnesota state line to Lake Michigan in Milwaukee.