The film tells the story of a bug exterminator, who, with the help of a hospital security guard and the military, battles a giant spider that goes on a rampage in Los Angeles.

Meanwhile, a U.S military task force led by Major Braxton Tanner and Lieutenant Karly Brant show up at the hospital to examine the dead body the spider burst out of.

The spider is driven off by Karly and escapes into a grate down into the sewer, where it sprays acid at and kills a homeless man.

After Alex and José demand answers, Braxton reveals that they discovered alien DNA and hoped to use it as a growth hormone.

As they enter the skyscraper, Braxton informs them that Karly is located directly inside the nest, and warns them of an impending airstrike.

José grabs a rocket launcher from a military vehicle and tosses it to Alex, who shoots the spider in the spinneret.

delivers on the promise of its outlandish title with a tongue-in-cheek creature feature that embraces its B-movie silliness with utterly entertaining result".

[3] Scott Foundas of Variety gave a positive review, calling the film "an exceedingly good-natured Z-grade creature feature."

[5] John DeFore of The Hollywood Reporter wrote positively of the film, saying "Mike Mendez's shamelessly Corman-esque Big Ass Spider!

"[6] Neil Genzlinger of The New York Times gave a negative review of the film, branding it as a "humorless horror comedy".

He concluded by saying that "the director, Mike Mendez, shows no signs of knowing how to make campy horror work the way that the creators of similar movies on Syfy do.

"[7] Rex Reed rated the film a 1 out of 4, saying that it was "lazily directed" and "aims for satire and settles for stale shtick".