Wise's other television roles include Vice President Hal Gardner in 24 (2006), The Devil in Reaper (2007–2009), Ian Ward in The Young and the Restless (2014–2016, 2024–2025) and Marvin in Fresh Off the Boat (2015–2020).

[4] In 1987, Wise played Tom Gunther, Catherine Chandler's boyfriend, in the pilot episode of the TV series Beauty and the Beast.

In 1995, Wise was reunited with Twin Peaks castmate Sherilyn Fenn in the NBC telemovie Liz: The Elizabeth Taylor Story.

He briefly appeared on The West Wing as California governor Gabriel "Gabe" Tillman, and played Vice President Hal Gardner on 24 in 2006.

In Season 8, episode 13 of Law & Order: Special Victims Unit (2007), Wise guest starred as the head of a company testing pesticides on little children.

He starred in Charmed as the upper level demon Ludlow, who runs a school for the Source Of All Evil in the episode "Lost and Bound".

Wise appeared in several episodes of Mad Men as Ken Cosgrove's father-in-law Ed Baxter, the CEO of Corning, Inc.

In 2010, Wise guest-starred as fictitious sports agent Bobby Fox alongside a special guest appearance from real life ex-Yankees manager Joe Torre on the TV series Castle, in the Season 2 episode "Suicide Squeeze".

That same year, Ray played John Nelson, A disturbed ex-mortician obsessed with trying to help his wife Linda in the Criminal Minds Season 8 episode "God Complex".

In 2017, he appeared as a guest in the TV series Fargo, as Paul Marrane, a kitten-handler and metaphysical punisher, in the episodes "The Law of Non-Contradiction" and "Who Rules the Land of Denial?"

He played the character of Dr. Alec Holland in the 1982 film Swamp Thing, directed by Wes Craven and based upon the comic book series of the same name.

He then played the roles of entrepreneur/millionaire Dalton Voss in The Chase (1994), Dr. Stripler in Powder (1995), Sheriff Blaidek in Evasive Action (1998), and Bart's father Harrison in The Battle of Shaker Heights (2003).

[8] In 2016, Wise starred as attorney Peter Kane in the film God's Not Dead 2, who represents the ACLU in its fight to have the protagonist, Grace Wesley (Melissa Joan Hart), convicted of proselytizing in a public school.

[10] He is also known for portraying Michael Dugan, President of the United States, in the full-motion video cutscenes for the computer real-time strategy game Command & Conquer: Red Alert 2 and its expansion, Yuri's Revenge.

In 2014, Wise starred in an original Chipotle web series titled Farmed and Dangerous; he played Buck Marshall in the satirical black comedy-type situation comedy.