Most stories in Big Bang Comics take place either on "Earth-A" during the 1960s, or on "Earth-B" during the 1940s, featuring characters such as Ultiman, Thunder Girl, and Dr. Weird.

The Comic Crusader Storybook was a trade paperback fanzine anthology which included short stories featuring the work of many independent artists and writers.

In 1993, Carlson and Edward DeGeorge acquired all rights to Dr. Weird from Howard Keltner, eventually folded him into the Big Bang universe and making him the only character with a genuine pedigree.

Like its predecessor series Big Bang Comics, this is an anthology featuring a rotating cast of new and established characters in a self-contained fictional universe, written by Carlson and drawn by Ecker and various other artists.

[citation needed] All of these false covers appeared on the reverse of the Caliber Press limited series issues in scaled-down shots, and again as full-page replicas in Big Bang #0.