Big Hits and Nasty Cuts: The Best of Twisted Sister is a greatest hits compilation by American heavy metal band, Twisted Sister.

It was released in 1992 by Atlantic Recording Corporation for the United States and by WEA International Inc. for the rest of the world.

The track list consists solely of songs from their first three albums, omitting any material from Come Out and Play and Love Is for Suckers, except outside of the United States where "Bad Boys of Rock 'n' Roll" was replaced with "Be Chrool to Your Scuel" from Come Out and Play.

The album received a Parental Advisory sticker for the live tracks, which contain some profanity.

Twisted Sister frontman Dee Snider was against the release of the compilation, citing it as nothing more than Atlantic Records' attempt to make profit off the band's back catalogue.