Big Lake is a village in western Holt County, Missouri, United States.

Big Lake is about ten miles (16 km) from the village of Rulo, Nebraska.

39.3% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older.

The racial makeup of the village was 98.43% White, 0.79% Native American, and 0.79% from two or more races.

33.3% of all households were made up of individuals, and 13.3% had someone living alone who was 65 years of age or older.

There were 4.7% of families and 5.9% of the population living below the poverty line, including no under eighteens and 11.4% of those over 64.