The Big Sandy River is both an intermittent and perennial stream in Mohave and La Paz counties in northwestern Arizona in the United States.

It begins where Cottonwood Wash and Trout Creek converge in the Hualapai Indian Reservation east of U.S. Route 93 then flows past Wikieup south of Kingman.

[3] The Big Sandy drainage basin covers approximately 2,000 square miles (5,200 km2) in Mohave, La Paz, and Yavapai counties.

Wild Burros, a protected species, live in the river valley along with ring-tailed cats, mountain lions, coyote, and elk.

In 2001, the Line Siting Committee of the Arizona Corporation Commission voted 8–1 to deny a request to build a power plant in the basin, on grounds of environmental incompatibility.

"[9] The agreement allows Freeport to pump and divert an additional 10,055 acre-feet (343 million gallons) of water per year from the Big Sandy Basin.