Katheryn Winnick and Kylie Bunbury star as a pair of investigators who team up to work on multiple cases in Montana.

Box's novel The Highway and developed by David E. Kelley, was announced as The Big Sky in January 2020 and given a straight-to-series order by ABC.

[9] John Carroll Lynch, Dedee Pfeiffer, Ryan Phillippe, and Katheryn Winnick were the first cast additions announced through February 2020.

[88] in December 2020, Camille Sullivan, Chad Willett, Patrick Gallagher, and Sharon Taylor joined the cast in recurring capacities.

[93] On September 21, 2021, Vinny Chhibber, Romy Rosemont, Ryan O'Nan, Michael Malarkey, and David Meunier joined the cast in recurring roles for the second season.

[18] On July 18, 2022, it was announced that J. Anthony Pena was promoted to a series regular while Luke Mitchell, Seth Gabel, Henry Ian Cusick, Anirudh Pisharody, and Madalyn Horcher were cast in recurring roles for the third season.

[94] One week later, it was confirmed that Jesse James Keitel, Anja Savcic, Janina Gavankar, Logan Marshall-Green and Vinny Chhibber won't return for the third season.

[19] Filming on the series' first season began on August 27, 2020, and concluded on April 24, 2021, in Vancouver, with the outdoor, mountainous wilderness around Squamish and Fraser Valley, plus various other locations in British Columbia[96] with aerial shots of Helena, Montana's capital.

[97] Filming was originally set to take place in Albuquerque, New Mexico, and Las Vegas, Nevada, but the series was moved to Vancouver in July 2020, due to the COVID-19 pandemic in the United States.

[98] The series was one of many American television productions in Vancouver that briefly halted filming in late September 2020, due to delays in receiving cast and crew COVID-19 test results.

The website's critics consensus reads, "Big Sky's shaky setup doesn't do it many favors, but viewers who can push through may find its fast-paced, twisty mystery compelling enough.

[107] After the pilot aired, members of the Rocky Mountain Tribal Leaders Council, Coushatta Tribe of Louisiana, Global Indigenous Council, Great Plains Tribal Chairmen's Association, and the Union of British Columbia Indian Chiefs (UBCIC), among others, addressed a letter to ABC Entertainment President Karey Burke and series creator David E. Kelley, accusing the show of "at best, cultural insensitivity, and at worst, appropriation" due to being set in an area with a disproportionately high rate of Murdered and Missing Indigenous Women & Girls (MMIWG), yet not having any tribal representation in the show.