[1][2][3] Three young, female lawyers share a deep friendship and a common desire to leave their mark on the legal system.

After graduating, they move to San Francisco where they find employment in the same law firm called Myers, Berry, Cherry & Fitch.

In describing the concept of girls club Kelley said, "I'm looking to capture both the nerves of a young associate and also the gender politics that go on inside big corporate law firms.

"[4] Fox added Girls Club to its Monday night schedule for Fall 2002 sight-unseen based on the success of creator David E. Kelley's previous series.

The series was consistently the lowest-rated show in the 18–49 demographic in its time slot, even being outrated by The WB's Everwood and UPN's Girlfriends.