Big Stone Gap is a 2014 American drama romantic comedy film written and directed by Adriana Trigiani and produced by Donna Gigliotti for Altar Identity Studios, a subsidiary of Media Society.

Based on Trigiani's 2000 best-selling novel of the same name, the story is set in the actual Virginia town of Big Stone Gap circa 1970s.

In 1978, 40-year-old independent woman Ave Maria Mulligan owns her dead father's pharmacy in her hometown of Big Stone Gap, Virginia.

Ave is heavily involved in her community, home delivering medications to the country folk, volunteering on the coal mining town's Emergency Response Team, and directing the town's annual production of "Trail of the Lonesome Pine", based on the novel by John Fox Jr. Ave delivers medications to Nan McChesney and is pleased to see Nan's son Jack, a local coal miner and a former schoolmate.

During the cast after-party for “Lonesome Pine”, it is announced that senatorial hopeful John Warner will make a campaign stop in town with his wife, Elizabeth Taylor, and Theodore will plan the event.

He accepts her offer of a lift home but Sweet Sue arrives and jumps into his arms, shrugging off Ave. Ave stumbles across old love letters between her momma and her real father, causing Ave's best friend, town librarian and local romantic Iva Lou, to confront her about non-existent love life.

They take an evening walk and he tells her that he broke up with Sue, as he has always had a crush on the little Italian girl that sat beside him in elementary school.

In an act of desperation, Iva Lou has Pearl confront Jack, asking him to help bring Ave out of her sleep, telling him they are meant for each other.

Aunt Alice and Uncle Wayne barge into the reception, furious about the pharmacy and stating that Ave won't be giving away the family home.

Ave's last day in Big Stone Gap, Theodore takes her to the Outdoor Theater, where all her friends are gathered on stage.

Theodore has the theater choir sing a song with Aunt Maria, while Jack's voiceover explains that he and Ave married and had two children.