In 2005, Mannie Fresh resigned from Cash Money due to financial disputes with Birdman and his brother, Ronald "Slim" Williams, effectively dissolving the duo.

In 2018, the duo reunited for the song "Designer Caskets", released for the Cash Money Records documentary soundtrack album Before Anythang.

This re-release substitutes a remix of "Stun'n" for the original version and adds "Big Ballin'", "Money & Power", and "Drop It Like It's Hot.

As of May 2013, Birdman, Lil Wayne and Drake have been in talks of restarting the group with an upcoming album, while original member Mannie Fresh would not be included.

[6] While doing promotion for the Rich Gang, Birdman indicated that a Big Tymers single would be released in Fall of 2013 with a possibility that Mannie Fresh may also be involved with the album.

In 2018, the duo reunited on a new track called "Designer Caskets" (it being their first song in 14 years) for the soundtrack of the Before Anythang: The Cash Money Story documentary.