William Chen (born 1970 in Williamsburg, Virginia) is an American quantitative analyst, poker player, and software designer.

Chen holds a Ph.D. in mathematics (1999) from the University of California, Berkeley.

[3] He was an undergraduate at Washington University in St. Louis triple-majoring in Physics, Math, and Computer Science, and was also a research intern in Washington University's Computer Science SURA Program where he co-wrote a technical report inventing an Argument Game.

He heads the Statistical arbitrage department at Susquehanna International Group.

In February 2009, he appeared on Poker After Dark's "Brilliant Minds" week, finishing in 5th place after his A♦ 3♦ lost to Jimmy Warren's A♠ A♥ after Chen pushed all-in on a flop of A♣ 3♣ Q♦.