William Leopold Hoffer (November 8, 1870 – July 21, 1959) was an American professional baseball player.

He was a right-handed pitcher over parts of six seasons (1895–1899, 1901) with the Baltimore Orioles, Pittsburgh Pirates and Cleveland Blues.

In 1901 he archived the dubious honor of being the losing pitcher in the American League's first game.

[1] In his rookie year, 1895, he compiled 31 wins (including a league-leading four shutouts) for the League-winning Orioles.

This biographical article relating to an American baseball pitcher born in the 1870s is a stub.