William E. Niles (January 11, 1867 – July 3, 1936) was a Major League Baseball player.
Niles played for Pittsburgh Pirates in the 1895 season.
He played just eleven games in his career, having eight hits in 37 at-bats, a .216 batting average.
Niles was born in Covington, Kentucky, and died in Springfield, Ohio.
This biographical article relating to an American baseball infielder is a stub.