[4] In 1983, Prady was a production assistant for The Jim Henson Company on a proposed television special centering on the world of technology.

He also served as a writer and producer on Good Morning, Miami, Caroline in the City, Related, Platypus Man and Gilmore Girls.

[5][9] In 2007, Prady co-created the CBS sitcom The Big Bang Theory, on which he served as executive producer for the show's 12-season run.

[10] In April 2015, it was announced that ABC had picked up Prady's pilot presentation for a new version of The Muppet Show with Bob Kushell attached as showrunner.

In 2022, he entered a similar agreement with Warner Bros. Television to develop scripted programming under his production company Pine Tree Entertainment.