William Henry Sherdel (August 15, 1896 – November 14, 1968) was an American professional baseball player.

He was a left-handed pitcher over parts of fifteen seasons (1918–1932) with the St. Louis Cardinals and Boston Braves.

[1] Sherdel was a member of two National League pennant-winning Cardinals teams, in 1926 and 1928, winning the World Series in 1926.

During World Series play, he compiled a 0–4 record in four appearances, with a 3.26 earned run average and six strikeouts.

Sherdel was an above-average hitting pitcher during his fifteen-year major league career.