Sir William Henry Spooner, KCMG, MM (23 December 1897 – 14 July 1966) was an Australian politician who served as a Senator for New South Wales from 1950 to 1965, representing the Liberal Party.

In 1918, Spooner joined the Australian Flying Corps and was commissioned a second lieutenant, completing his war service in August 1919.

In January 1945, the LDP subsequently merged into the new Liberal Party of Australia, and Spooner was chosen as chairman of the provisional executive for the New South Wales division.

Although his Senate term began on 22 February 1950, he was sworn in as Minister for Social Services in the Menzies government on 19 December 1949.

His portfolio was responsible for policy towards the mining industry, especially coal, oil, uranium and iron ore.

The Canberra Times reported that he was only the second senator to serve as acting prime minister, after George Pearce in 1916.