On February 15, 2019, former Massachusetts Governor Bill Weld announced the formation of an exploratory committee to consider running for the Republican nomination in the 2020 United States presidential election.

[9] On February 15, 2019, Weld officially announced the formation of an exploratory committee in preparing to run for the 2020 Republican Party presidential primaries.

On Morning Joe, he criticized Donald Trump as president, with a focus especially on what he labeled bad foreign policy in regards largely to North Korea and Russia.

He said that recent abortion laws passed by states, such as Alabama's Human Life Protection Act, left him feeling "terrible".

"We've got the polar ice cap that's going to melt with devastating consequences if we don’t get carbon out of the atmosphere," Weld told "America's Newsroom," nothing that he would plan ahead for an "environmental catastrophe.

[22][23][24] On Monday, April 15, 2019, Weld formally announced his candidacy for President of the United States on The Lead with Jake Tapper.