He also played the recurring role of John Justice Wheeler in the second season of the TV series Twin Peaks, and provided the voice of Ansem in the video game Kingdom Hearts (2002).

Earlier that same year, Zane gained international recognition with the role of villain Hughie Warriner in the thriller Dead Calm, alongside Nicole Kidman and Sam Neill.

He also starred in the NBC film The Case of the Hillside Stranglers (1989), and Adam Sandler's "no budget" debut Going Overboard (1989) which was not released to a wider audience until 1996.

Zane also forayed into television work, and in 1991 he appeared as John Justice Wheeler in several episodes of David Lynch's hit TV-show Twin Peaks.

In 1993, he played the Shakespearean actor "Mr. Fabian" in Tombstone, took a starring role in Sniper he also starred alongside Mario Van Peebles as a cold-blooded and corrupt Colonel Graham in Posse and also in Lake Consequence and played a playboy named Harry, posing as the elusive, albeit fake Damon Bradley alongside Marisa Tomei and Robert Downey Jr. in Only You.

In 1998, he starred in and produced I Woke Up Early the Day I Died, a silent film based on Ed Wood's last script, intended as a parody on bad filmmaking.

The year after, he starred opposite Timothy Dalton, Bruce Payne, Sean Pertwee and Leonor Varela (who became his fiancé after shooting ended) in a TV-movie about Cleopatra.

The same year, he voiced John Rolfe in Disney's Pocahontas II: Journey to a New World and Etrigan the Demon in an episode of The New Batman Adventures.

He also provided the voice of Ansem, the main antagonist of the 2002 video game Kingdom Hearts, opposite Haley Joel Osment.

The film tells the story of the U.S. Army run amok in Iraq, eventually brought into check by a Turkish soldier.

[10] Zane starred in the 2012 action/thriller film The Kill Hole,[11] and in January 2017 he appeared in a commercial for KFC as a gold-colored Colonel Sanders to pitch the restaurant chain's newest limited-time flavor, Georgia Gold Honey Mustard BBQ chicken.

Zane was also featured in two episodes of The Boys portraying a fictional version of himself who made a movie with Popclaw and also attended a comic convention with Tara Reid.