The $35 million facilities, named one of the best schools in the country by the U.S. Department of Education in 2006, features a campus nestled on about 90 acres (360,000 m2) between the Back Bay of Biloxi and Interstate 10.

This facility includes fully equipped science laboratories; computer labs; a 200-seat performance hall; practice and competition gymnasiums; tennis courts; a football stadium; baseball and softball stadiums with indoor batting cages; music areas with individual practice rooms and risers; and kilns in the art classrooms.

With an estimated 14 million dollar price tag, the addition was funded with monies split between existing gaming revenues and property taxes.

Biloxi High School also offers a range of classes in its vocational department from child care to auto body.

AP students are often allowed opportunities, including the We the People experience, History Day, and the Stock Market Game.

The main goal of the Hi-Tide is to keep students, faculty, staff, and community members informed of current events at Biloxi High School.

The National Honor Society is an honorary association made up of students who excel in scholarship, character, leadership, and service.

Students often schedule a workday outside of normal school hours to help keep Biloxi High's Nature Trail environmentally clean and available for other classes and visitors.

The Environmental Club at BHS also raises money to sponsor Biloxi High's Canon Envirothon Competition Team.

Each year, a team of five students with one alternate attends a local competition and competes for scholarships in areas such as aquatics and water quality, soil science, forestry and land management, and wildlife.

Tri-M is a national honor society that deals in the musical education needed for growing musicians around the country.