[2] SRI International,[3] based in Menlo Park, California, maintains the BioCyc database family.

[5] The remaining five databases include, EcoCyc (E. coli),[6] AraCyc (Arabidopsis thaliana), YeastCyc (Saccharomyces cerevisiae), LeishCyc (Leishmania major Friedlin) and TrypanoCyc (Trypanosoma brucei).

The ontological resource contains a variety of software tools for searching, visualizing, comparing, and analyzing genome and pathway information.

The website also includes tools for painting large-scale ("omics") datasets onto metabolic and regulatory networks, and onto the genome.

SNPs The study by Shimul Chowdhury et al.[8] showed association differed between maternal SNPs and metabolites involved in homocysteine, folate, and transsulfuration pathways in cases with Congenital Heart Defects (CHDs) as opposed to controls.