The film opens with a series of unsuccessful assassination attempts by an unknown organisation with their target being Melvin Byrd.

Byrd is a janitor in a NASA laboratory headed by Major General Smithburn with his security officer being an inept bungler, Lt. Porter.

When General Smithburn leads a Congressional delegation who are in Florida due to European junkets being cancelled, Byrd hides in the ionization machine, causing him to be ionized.

In addition to losing the ability to stay on the ground for longer than brief periods, Byrd finds himself forced to fight off the attentions of a Congresswoman and Waid's daughter Claudine as well as the assassins.

Producer Ivan Tors filmed Birds Do It at his Miami studios with cameos provided by Dean Martin (Columbia's Matt Helm), Flipper, director Andrew Marton as himself, and a Cary Grant impersonator played by Ray Anthony.